ABSTRACT
Cytokine storm is one of the mechanisms causing acute respiratory distress syndrome and multiple organ failure in COVID-19. As an important prognostic factor, cytokines have gradually become a hotspot in the research on treatment of COVID-19 in recent years. Based on literature regarding the key cytokines, related signaling pathways and existing therapeutic drugs of COVID-19 cytokine storm, this article summarizes the therapeutic drugs for COVID-19 that block the cytokine storm signaling pathways. After summarizing and analyzing the latest research results, it is proposed that therapeutic drugs with stronger targeting capacity could be the focus of COVID-19 drug development in the future, and different treatment regimens should be adopted for different patients.